The Membrane Scaffold CD82 Regulates Acute Myeloid Leukemia Dormancy and Bone Marrow Niche Interactions
نویسندگان
چکیده
منابع مشابه
Adhesion to osteopontin in the bone marrow niche regulates lymphoblastic leukemia cell dormancy.
Malignant cells may evade death from cytotoxic agents if they are in a dormant state. The host microenvironment plays important roles in cancer progression, but how niches might control cancer cell dormancy is little understood. Here we show that osteopontin (OPN), an extracellular matrix molecule secreted by osteoblasts, can function to anchor leukemic blasts in anatomic locations supporting t...
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1Hospital de Clínicas de Porto Alegre – HCPA, Porto Alegre, RS, Brazil 2Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo USP, São Paulo, SP, Brazil 3Hospital de Câncer de Barretos, Barretos, SP, Brazil 4Universidade Federal de São Paulo – UNIFESP, São Paulo, SP, Brazil 5Hospital Araújo Jorge – HAJ, Goiânia, GO, Brazil 6Hospital Israelita Albert Einstein HIAE, São Paulo, S...
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Patients with acute myeloid leukemia (AML) have increased myeloid cells within their bone marrow that exhibit aberrant signaling. Therefore, therapeutic targets that modulate disrupted signaling cascades are of significant interest. In this study, we demonstrate that the tetraspanin membrane scaffold, CD82, regulates protein kinase c alpha (PKCα)-mediated signaling critical for AML progression....
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ژورنال
عنوان ژورنال: Blood
سال: 2019
ISSN: 0006-4971,1528-0020
DOI: 10.1182/blood-2019-129320